Hritik Arasu

Real-time closed-loop neurofeedback based on functional magnetic resonance imaging (fMRI) has led to important scientific and clinical advances. However, the sophistication of the analysis methods used in real-time fMRI lags behind the state-of-the-art in fMRI decoding, largely due to computational factors: Most advanced decoding pipelines do not fit within the envelope of real-time processing, where the analysis needs to be conducted in a matter of seconds and without leveraging data acquired later in the session. Here, we present a real-time compatible adaptation of a computationally intensive state-of-the-art pipeline for reconstructing perceived natural images (MindEye2), and we demonstrate that reliable fine-grained decoding is still achievable in this setting. Using RT-Cloud, an open-source, scalable cloud-based platform, we performed a real-time scan where we decoded single-trial visual perception within seconds after an image was shown to the participant. Finally, we use simulated analyses to document the factors driving changes in performance from offline to real-time analysis. This work serves as a proof-of-concept that it is feasible to deploy these powerful fMRI decoding pipelines in real-time analysis, paving the way for their use in brain-computer interfaces for scientific discovery and clinical treatment.

Sleep staging models often degrade when deployed on patients with unseen physiology or recording conditions. We propose a streaming, source-free test-time adaptation (TTA) recipe that combines entropy minimization (Tent) with Batch-Norm statistic refresh and two safety rails: an entropy gate to pause adaptation on uncertain windows and an EMA-based reset to reel back drift. On Sleep-EDF Expanded, using single-lead EEG (Fpz-Cz, 100 Hz, 30s epochs; R&K to AASM mapping), we show consistent gains over a frozen baseline at seconds-level latency and minimal memory, reporting per-stage metrics and Cohen’s kappa. The method is model-agnostic, requires no source data or patient calibration, and is practical for on-device or bedside use.

Artifacts in electroencephalography (EEG) – muscle, eye movement, electrode, chewing, and shiver – confound automated analysis yet are costly to label at scale. We study whether modern generative models can synthesize realistic, label-aware artifact segments suitable for augmentation and stress-testing. Using the TUH EEG Artifact (TUAR) corpus, we curate subject-wise splits and fixed-length multi-channel windows (e.g., 250 samples) with preprocessing tailored to each model (per-window min-max for adversarial training; per-recording/channel z-score for diffusion). We compare a conditional WGAN-GP with a projection discriminator to a 1D denoising diffusion model with classifier-free guidance, and evaluate along three axes: (i) fidelity via Welch band-power deltas, channel-covariance Frobenius distance, autocorrelation L2, and distributional metrics (MMD/PRD); (ii) specificity via class-conditional recovery with lightweight kNN/classifiers; and (iii) utility via augmentation effects on artifact recognition. In our setting, WGAN-GP achieves closer spectral alignment and lower MMD to real data, while both models exhibit weak class-conditional recovery, limiting immediate augmentation gains and revealing opportunities for stronger conditioning and coverage. We release a reproducible pipeline – data manifests, training configurations, and evaluation scripts – to establish a baseline for EEG artifact synthesis and to surface actionable failure modes for future work.